Bioorganic & medicinal chemistry letters

Design and synthesis of releasable folate–drug conjugates using a novel heterobifunctional disulfide-containing linker

A Satyam

Index: Satyam, Apparao Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3196 - 3199

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Citation Number: 38

Abstract

Cellular uptake of vitamin folic acid occurs via folate-receptor mediated endocytosis. Many types of cancer cells express high levels of folate receptors as they need continuous supply of this vitamin for their proliferation. With an objective to use folic acid as a 'Trojan Horse'to transport anticancer drugs into cancer cells, a novel heterobifunctional disulfide-containing linker was synthesized and utilized to covalently link an amino-and hydroxyl-containing ...