Studies on antianaphylactic agents. 6. Synthesis of some metabolites of 6-ethyl-3-(1H-tetrazol-5-yl) chromone and their analogs

A Nohara, H Kuriki, T Ishiguro, T Saijo…

Index: Nohara; Kuriki; Ishiguro; Saijo; Ukawa; Maki; Sanno Journal of Medicinal Chemistry, 1979 , vol. 22, # 3 p. 290 - 295

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Citation Number: 26

Abstract

The metabolites of 6-ethyl-3-(1H-tetrazol-5-yl) ehromone (AA-344)(I), an orally effective antiallergic agent, and their analogues were synthesized to confirm the proposed structures and to determine their activity in the rat passive cutaneous anaphylaxis (PCA) test A glucuronic acid metabolite (6) was assigned the structure 24b, 1-deoxy 1-[~-(6-etliylchromon- 3-yl) tetrazol-l-yl]-~-~-glucopyranuronate, by the comparison of I3C NMR, mass spectra, ...