Organic letters

Intramolecular Methylation of an Allyl Sulfone via Lithium Alkoxyaluminate; Application to the Enantioselective Synthesis of the CD Ring of Vitamin D3

V Sikervar, PL Fuchs

Index: Sikervar, Vikas; Fuchs, Philip L. Organic Letters, 2012 , vol. 14, # 11 p. 2922 - 2924

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Citation Number: 4

Abstract

1α,25(OH) 2 D 3 is the most biologically active metabolite of Vitamin D 3 and is involved in the regulation of calcium homeostasis and bone metabolism (Figure 1). In addition, it suppresses the growth of numerous human cancer cell lines by inhibiting cell cycle progression and inducing cell death. There has been enormous research on the development of analogs of Vitamin D 3 that are more potent than natural Vitamin D 3 . CD ring modification has also made a ...