Synthesis and investigation of anti-inflammatory activity of novel nitric oxide donating hybrid drugs

SL Chandak, AS Bansode, PR Murumkar…

Index: Chandak, Shailesh L.; Bansode, Amol S.; Murumkar, Prashant R.; Shinde, Monika G.; Bothara, Kailash G. Medicinal Chemistry Research, 2013 , vol. 22, # 7 p. 3510 - 3517

Full Text: HTML

Citation Number: 2

Abstract

Abstract A small library of nitric oxide donating groups, 4-acetamidophenyl-2-[{2-(nitrooxy) ethyl}(phenyl) amino] benzoate (5a–e) possessing a variety of substituents (–H,–NO 2,–CH 3,–acetamidophenyl,–SO 2 NH 2) attached to the fourth position of phenyl ring were synthesized and evaluated for anti-inflammatory, analgesic and ulcerogenic potential. Structure–activity relationship data showed that the 2-phenylaminobenzoic acid skeleton ...