Nature of the Acetyl Cholinesterase Surface. II. The Ring Effect in Enzymatic Inhibitors of the Substituted Ethylenediamine Type1

SL Friess, WJ McCarville

Index: Friess; McCarville Journal of the American Chemical Society, 1954 , vol. 76, p. 2260

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Citation Number: 16

Abstract

3a-chloro-6, 7-secocholestane-6, 7-dioic acid anhydride (I). Windaus and Stein'reported that 3a-chloro-6, 7-secocholestane-6, 7-dioic acid (11) formed a crystalline anhydride melting at 187'. No further data on this compound were reported. A re-examination of this reaction produced a substance of the indicated melting point, the structure of which was, however, established to be 3a-chloro-B-norcoprostane-&one (111). Therefore, this ring closure ...