Novel non-peptide nociceptin/orphanin fq receptor agonist, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3 R)-3-piperidinyl]-1 H-benzimidazole: Design, synthesis, and …

…, Y Murata, K Ohashi, E Nakata

Index: Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807

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Citation Number: 29

Abstract

... KCN, TsOH, H 2 O, 45 °C; (d) MeMgBr/THF, CH 2 Cl 2 , −78 °C to room temp; (e) NH 2 OH·HCl, EtOH/H 2 O, reflux; (f) 1-fluoro-2-nitrobenzene, K 2 CO 3 , CH 3 CN, reflux; (g) Zn, NH ... CH 2 Cl 2 , −30 °C to room temp; (b) AcOH, toluene, 100 °C; (c) 10% HCl in MeOH; (d) LAH, THF ...