Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines

K Patel, C Karthikeyan, V Raja Solomon…

Index: Patel, Kuldeep; Karthikeyan, Chandrabose; Solomon, Viswas Raja; Moorthy, N.S. Hari Narayana; Lee, Hoyun; Sahu, Kapendra; Deora, Girdhar Singh; Trivedi, Piyush Letters in Drug Design and Discovery, 2011 , vol. 8, # 4 p. 308 - 311

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Citation Number: 19

Abstract

A series of coumarinyl chalcones derivatives were synthesized and evaluated for their antiproliferative activities on three different breast cancer cell lines (MDA-MB231, MDA- MB468, MCF7) and one non-cancer breast epithelial cell line (184B5). The coumarinyl derivatives exhibited anticancer activity against breast cancer cell lines at a micromolar range. A structure-activity relationship (SAR) analysis was performed by studying the ...