Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro

TT Chang, SV More, IH Lu, JC Hsu, TJ Chen…

Index: Chang, Tzu Ting; More, Shivaji V.; Lu, I.-Hsuan; Hsu, Jui-Ching; Chen, Ting-Ju; Jen, Ya Ching; Lu, Chung-Kuang; Li, Wen-Shan European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3810 - 3819

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Citation Number: 30

Abstract

Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3–9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to ...