Efficient conversion of carboxylic acids into N-acylbenzotriazoles
AR Katritzky, Y Zhang, SK Singh
Index: Katritzky, Alan R.; Zhang, Yuming; Singh, Sandeep K. Synthesis, 2003 , # 18 p. 2795 - 2798
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Citation Number: 77
Abstract
Our new procedure involves reaction of 1 equivalent of a carboxylic acid with 4 equivalents of benzotriazole and 1 equivalent of thionyl chloride in CH 2 Cl 2 at room temperature for 2 hours. Success with a wide range of carboxylic acids demonstrates the general applicability of this procedure (Table [1] ). Aliphatic short chain propionic acid, long chain palmitic acid, and alicyclic 1-phenyl-cyclopropanecarboxylic acid gave the corresponding ...
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