Tetrahedron Letters

Z-Selective intramolecular Horner–Wadsworth–Emmons reaction for the synthesis of macrocyclic alkenes

K Ando, K Sato

Index: Ando, Kaori; Sato, Kaori Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1284 - 1287

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Citation Number: 9

Abstract

The Z-selective intramolecular Horner–Wadsworth–Emmons reaction of the substrates 7–12 (RO) 2P (O) CHR′ CO2Et (R′=(CH2) nCHO)(R= Ph or o-tBuC6H4) gives the 13–18- membered cyclic alkenes selectively (up to Z: E= 97: 3) in good yields using NaH in THF under high dilution conditions.