Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequences

Y Chai, A Paul, M Rettig, WD Wilson…

Index: Chai, Yun; Paul, Ananya; Rettig, Michael; Wilson, W. David; Boykin, David W. Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 852 - 866

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Citation Number: 14

Abstract

The compounds synthesized in this research were designed with the goal of establishing a new paradigm for mixed-base-pair DNA sequence-specific recognition. The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base pair sites in the DNA minor groove. Modifications were introduced in the original compound to include an H-bond accepting group to specifically recognize the G-NH that projects into the minor groove. ...