Normal and abnormal heme biosynthesis. 1. Synthesis and metabolism of di-and monocarboxylic porphyrinogens related to coproporphyrinogen-III and …

TD Lash, UN Mani, MA Drinan, C Zhen…

Index: Al-Hazimi, Hassan M. G.; Jackson, Anthony H.; Knight, David W.; Lash, Timothy D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 265 - 276

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Citation Number: 33

Abstract

Coproporphyrinogen oxidase (copro'gen oxidase), which catalyses the conversion of coproporphyrinogen-III via a monovinylic intermediate to protoporphyrinogen-IX, is one of the least well understood enzymes in the heme biosynthetic pathway. To develop a model for the substrate recognition and binding recognition for this enzyme, a series of substrate analogues were prepared with two alkyl substituents on positions 13 and 17 in place of ...