Anticonvulsant activity and selective inhibition of nicotinamide adenine dinucleotide??dependent oxidations by 10??(2??arylimino??3??acetylamino??4??thiazolidonyl) …

SP Singh, B Ali, TK Auyong, SS Parmar…

Index: Singh; Ali; Auyong; Parmar; De Boer Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 3 p. 391 - 396

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Citation Number: 16

Abstract

Abstract Several 10-(1-acetyl-4-arylthiosemicarbazido) phenothiazines and their corresponding cyclized 10-(2-arylimino-3-acetylamino-4-thiazolidonyl) phenothiazines were synthesized and characterized by their sharp melting points and elemental analyses. All compounds inhibited nicotinamide adenine dinucleotide (NAD)-dependent oxidation of pyruvate and α-ketoglutarate selectively, whereas NAD-independent oxidation of ...

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