Variation of xantphos-based ligands in the palladium-catalyzed reaction of aryl halides with ureas

AG Sergeev, GA Artamkina, IP Beletskaya

Index: Sergeev; Artamkina; Beletskaya Russian Journal of Organic Chemistry, 2003 , vol. 39, # 12 p. 1741 - 1752

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Citation Number: 14

Abstract

Abstract A series of Xantphos-based ligands containing various substituents in the diphenylphosphino groups were synthesized, and their effect on the product yield and ratio in the palladium-catalyzed arylation of ureas with nonactivated aryl halides was studied. The arylation of urea and phenylurea in the presence of Pd 2 (dba) 3-CHCl 3, 3, 5-(CF 3) 2 Xantphos, and Cs 2 CO 3 in dioxane at 100° C gave the corresponding N, N'-diarylureas ...

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