A stereodivergent strategy to both product enantiomers from the same enantiomer of a stereoinducing catalyst: Agelastatin A

BM Trost, G Dong

Index: Trost, Barry M.; Dong, Guangbin Chemistry - A European Journal, 2009 , vol. 15, # 28 p. 6910 - 6919

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Citation Number: 49

Abstract

Abstract In this article, we report a full account of our recent development of pyrroles and N- alkoxyamides as new classes of nucleophiles for palladium-catalyzed AAA reactions, along with application of these methodologies in the total synthesis of agelastatin A, a marine natural product with exceptional anticancer activity and other biological properties. Our method allows for access to either regioisomer of the pyrrolopiperazinones (6 and 19) with ...