Fluorinating Cleavage of Solid Phase Linkers for Combinatorial Synthesis

MS Wiehn, SD Lindell, S Bräse

Index: Wiehn, Matthias S.; Lindell, Stephen D.; Braese, Stefan Angewandte Chemie - International Edition, 2008 , vol. 47, # 42 p. 8120 - 8122

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Citation Number: 11

Abstract

Organofluorine compounds play an increasingly important role in the modern drug discovery process. While the first fluorine-containing agent was developed in the late 1950s,[1] today fluorinated pharmaceuticals and agrochemicals make up about 20% and 30% of their respective global markets.[2] In 2006 two fluorinated drugs, the cholesterol-reducer Lipitor (1) and the asthma agent Advair, were the top-selling prescription drugs.[3] Another ...