The Journal of Organic Chemistry

Chiral aziridinyl radicals: an application to the synthesis of the core nucleus of FR-900482

FE Ziegler, M Belema

Index: Ziegler, Frederick E.; Belema, Makonen Journal of Organic Chemistry, 1997 , vol. 62, # 4 p. 1083 - 1094

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Citation Number: 85

Abstract

An asymmetric route to the core nucleus of the antitumor agent FR-900482 utilizes the cyclization of an aziridinyl radical into a functionalized indole nucleus. The route employs a selective Polonovski reaction and the Hootelé-Dmitrienko rearrangement to install two ...