New 1, 2, 3, 9-tetrahydro-4H-carbazol-4-one derivatives: Analogues of HEAT as ligands for the α 1-adrenergic receptor subtypes

…, L Salerno, M Siracusa, F Russo, KP Minneman

Index: Romeo, Giuseppe; Materia, Luisa; Pittala, Valeria; Modica, Maria; Salerno, Loredana; Siracusa, Mariangela; Russo, Filippo; Minneman, Kenneth P. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5211 - 5219

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Citation Number: 22

Abstract

With the aim to develop new ligands able to discriminate among the three subtypes of α1- adrenergic receptors (α1A-AR, α1B-AR, and α1D-AR), a series of new 1, 2, 3, 9-tetrahydro- 4H-carbazol-4-ones bearing a 3-[[[2-(4-hydroxyphenyl) ethyl] amino] methyl] or a 3-[[4-(2- substitutedphenyl) piperazin-1-yl] methyl] side chain were synthesized. The general structure of the new compounds is reminiscent of HEAT and RN5, two potent α1-AR ...