Processing of cyclopropylarenes by toluene dioxygenase: isolation and absolute configuration of metabolites

KJ Finn, L Rochon, T Hudlicky

Index: Finn, Kevin J.; Rochon, Lena; Hudlicky, Tomas Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3606 - 3613

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Citation Number: 6

Abstract

Enzymatic oxidation of aromatics with recombinant organisms expressing toluene dioxygenase (TDO) provides valuable synthons for asymmetric synthesis. Several hundreds of cyclohexadiene cis-diols are already known 1 and many have found application in total synthesis of natural products. 1c and 2 Reliable procedures have been published for the whole-cell fermentation of arenes using either a recombinant organism 3 (Escherichia coli JM 109 pDTG601) or a ...