Synthesis and anticancer effect of B-ring trifluoromethylated flavonoids

X Zheng, JG Cao, WD Meng, FL Qing

Index: Zheng, Xing; Cao, Jian-Guo; Meng, Wei-Dong; Qing, Feng-Ling Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3423 - 3427

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Citation Number: 57

Abstract

A series of B-ring trifluoromethylated flavonoids derivatives were prepared and tested in vitro against human gastric adenocarcinoma cell line (SGC-7901). Among these derivatives, 5, 7- dipropoxy-2-(4′-trifluoromethylphenyl)-chromen-4-one 5c had the strongest activity against SGC-7901 cell.