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Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4 (3H)-ones

D Raffa, G Daidone, B Maggio, S Cascioferro, F Plescia…

Index: Raffa, Demetrio; Daidone, Giuseppe; Maggio, Benedetta; Cascioferro, Stella; Plescia, Fabiana; Schillaci, Domenico Farmaco, 2004 , vol. 59, # 6 p. 451 - 455

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Citation Number: 18

Abstract

3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4 (3H)-ones 8a–l and 9a, c–e, h–l were synthesized by refluxing in acetic acid the corresponding 2- methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a, c–e, h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic ...