A One-Pot, Solid-Phase Synthesis of Secondary Amines from Reactive Alkyl Halides and an Alkyl Azide
S Ayesa, B Samuelsson, B Classon
Index: Ayesa, Susana; Samuelsson, Bertil; Classon, Bjoern Synlett, 2008 , # 1 p. 97 - 99
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Citation Number: 5
Abstract
In a publication describing the use of a phosphonium diaza-diylides or a phosphonium aza-yldiide as reagent for the synthesis of primary and secondary amines [8] (Scheme [2] ) by a stepwise solution-phase dialkylation of an aza-yldiide, good yields were reported of N-alkyl phosphimines or disubstituted aminophosphonium salts, which by hydrolysis provided the corresponding primary or secondary amines. However, this methodology requires the use of strong base.
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