Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1β) production

T Matsuda, T Aoki, T Ohgiya, T Koshi, M Ohkuchi…

Index: Matsuda, Takayuki; Aoki, Taro; Ohgiya, Tadaaki; Koshi, Tomoyuki; Ohkuchi, Masao; Shigyo, Hiromichi Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2369 - 2372

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Citation Number: 13

Abstract

New pyridazine derivatives were prepared, and their abilities to inhibit IL-1β production were evaluated. Some compounds showed potent inhibitory activity against IL-1β production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure–activity relationships of these compounds are described.