Organic letters

Unusual approach to branched 3-alkynylamides and to 1, 5-dihydropyrrol-2-ones

I Dias-Jurberg, F Gagosz, SZ Zard

Index: Dias-Jurberg, Igor; Gagosz, Fabien; Zard, Samir Z. Organic Letters, 2010 , vol. 12, # 3 p. 416 - 419

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Citation Number: 22

Abstract

Rare carboxamide branched alkynes such as 11a can be readily obtained by reaction of the electrophilic 4-alkylidene isoxazolinones with isocycanides followed by nitrosative cleavage of the heterocyclic ring. N-Iodosuccinimide induced ring closure in the presence of a nucleophile results in the formation of new iodopyrrolinones such as 16c.