Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors

JA O'Meara, C Yoakim, PR Bonneau…

Index: Yoakim, Christiane; Guse; O'Meara; Thavonekham Synlett, 2003 , # 4 p. 473 - 476

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Citation Number: 27

Abstract

A series of novel 8-substituted dipyridodiazepinone-based inhibitors were investigated for their antiviral activity against wild type human immunodeficiency virus (HIV-1) and the clinically prevalent K103N/Y181C mutant virus. Our efforts have resulted in a series of benzoic acid analogues that are potent inhibitors of HIV-1 replication against a panel of HIV- 1 strains resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). ...