Synthesis, characterization and in vitro hydrolysis of a gemfibrozil-nicotinic acid codrug for improvement of lipid profile

AM Qandil, MM Rezigue, BM Tashtoush

Index: Qandil, Amjad M.; Rezigue, Meriem M.; Tashtoush, Bassam M. European Journal of Pharmaceutical Sciences, 2011 , vol. 43, # 3 p. 99 - 108

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Citation Number: 10

Abstract

Abstract Combination therapy of fibrates and nicotinic acid has been reported to be synergistic. Herein, we describe a covalent codrug of gemfibrozil (GEM) and nicotinic acid (NA) that was synthesized and characterized by 1 H NMR, 13 C NMR, FT-IR, MS analysis and elemental analysis. A validated HPLC method was developed that allows for the accurate quantitative determination of the codrug and its hydrolytic products that are ...