Tetrahedron

Reagent concentration effects in the REM resin solid phase synthesis of tertiary amines

JR Morphy, Z Rankovic, M York

Index: Morphy, J. Richard; Rankovic, Zoran; York, Mark Tetrahedron, 2003 , vol. 59, # 12 p. 2137 - 2145

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Citation Number: 16

Abstract

The use of reagent concentration has resulted in increased rates for all stages of the REM resin synthesis of tertiary amines. These increases in rate translate into faster reaction times, higher yields and lower reagent consumption. Of the methods examined, the most successful was the use of perfluorous solvents, either alone or with a small amount of organic co-solvent.

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