Tetrahedron letters

Chemoenzymatic synthesis of (3S, 4S)-and (3R, 4R)-3-methoxy-4-methylaminopyrrolidine

A Kamal, AA Shaik, M Sandbhor, MS Malik, H Kaga

Index: Kamal, Ahmed; Shaik, Ahmad Ali; Sandbhor, Mahendra; Malik, M. Shaheer; Kaga, Harumi Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8057 - 8059

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Citation Number: 13

Abstract

Facile chemoenzymatic enantioselective synthesis of (3S, 4S)-3-methoxy-4- methylaminopyrrolidine, a key intermediate for a new quinolone antitumor compound AG- 7352 has been described. This methodology illustrates the preparation of 3-azido-1- benzyloxycarbonyl-4-hydroxypyrrolidine starting from diallylamine via 1-benzyloxycarbonyl- 3-pyrroline obtained by ring-closing metathesis (RCM) employing Grubbs' catalyst. ...