Endogenous natriuretic factors 6: the stereochemistry of a natriuretic γ-tocopherol metabolite LLU-α

D Kantoci, WJ Wechter, ED Murray, SA Dewind…

Index: Kantoci, Darko; Wechter, William J.; Murray Jr., E. David; Dewind, Sally A.; Borchardt, Dan; Khan, Saeed I. Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 648 - 656

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Citation Number: 41

Abstract

Abstract 2, 7, 8-Trimethyl-(S)-2-(β-carboxyethyl)-6-hydroxy chroman (S-LLU-α) isolated from human uremic urine is apparently an oxidative side-chain degradation product of γ- tocopherol. This compound exhibits natriuretic activity in vivo and it appears to mediate the inhibition of the 70 pS K+ channel in the apical membrane of the thick ascending limb of the nephron. The stereochemistry at the C-2 of LLU-α has been unequivocally established to ...