Synthese von Thiomorpholin und 2-monoalkylierten Thiomorpholinen via 5, 6-Dihydro-1, 4-thiazine

F Asinger, H Offermanns, D Neuray, P Müller

Index: Asinger,F. et al. Monatshefte fuer Chemie, 1970 , vol. 101, p. 1295 - 1308

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Citation Number: 10

Abstract

Abstract Propionaldehyde, n-butyraldehyde and n-valeraldehyde react with ethylenimine in the presence of dimethylformamide or anhydrous K 2 CO 3 to mixtures of 2-monoalkylated 5.6-dihydro-4 H-1.4-thiazines (2–4) and 2-monoalkylated thiazolidines (6–8). When acetaldehyde is inserted in this reaction, solely 2-methyl-thiazolidine (5) could be isolated. By condensation of α-chloroaldehydes with the sodium salt of cysteamine 2-alkyl-5.6- ...