Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: New Selective Ligands of the 5-HT 7 Receptor

C Kikuchi, T Hiranuma, M Koyama

Index: Kikuchi, Chika; Hiranuma, Toyokazu; Koyama, Masao Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2549 - 2552

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Citation Number: 45

Abstract

The synthesis and the affinity for the 5-HT7 receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT7 receptor. Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles 5d and 5h are potent ligands for the 5-HT7 receptor, with high selectivity over the 5-HT2 receptor and other receptors. These compounds should be useful tools for clarifying the ...