Angewandte Chemie International Edition

Stereoselective Synthesis of Isoxazolidines through Pd??Catalyzed Carboetherification of N??Butenylhydroxylamines

MB Hay, JP Wolfe

Index: Hay, Michael B.; Wolfe, John P. Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6492 - 6494

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Citation Number: 34

Abstract

Isoxazolidines are frequently used as intermediates in the synthesis of complex molecules [1] and are found in several interesting biologically active compounds.[2] In addition, the isoxazolidine NÀO bond can be easily cleaved under reducing conditions to afford 1, 3- amino alcohols, which are also of synthetic utility.[3] The most commonly employed method for the construction of isoxazolidines involves 1, 3-dipolar cycloaddition reactions between ...