Enhancement of enantioselectivity in the optical resolution of primary alcohols with modified cyclodextrin colyophilized lipase

K Shioji, Y Kurauchi, K Terada, Y Kodera…

Index: Shioji, Kosei; Kurauchi, Yoshimitsu; Terada, Keiko; Kodera, Yasushi; Okuma, Kentaro Synthetic Communications, 2007 , vol. 37, # 13 p. 2163 - 2170

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Abstract

Abstract Colyophilization of lipase was carried out with immobilized β??cyclodextrins (β??CyD) bearing methyl, acetyl, benzoyl, and nicotinoyl substituents. The colyophilizates enhanced stereoselectivity in the acylation of several alcohols. The enantioselectivity in the acylation of ethyl??1??hydroxymethyl??phenylphosphine oxide using colyophilized lipase with nicotinoyl?螃漫? CyD increased approximately threefold (from E= 34 to E= 113). The amphiphilic character ...