Tetrahedron letters

Synthese de N-(tetrazol-5-yl) azetidin-2-ones

M Klich, G Teutsch

Index: Klich, Michel; Teutsch, Georges Tetrahedron Letters, 1984 , vol. 25, # 35 p. 3849 - 3852

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Citation Number: 18

Abstract

Abstract The title compounds were obtained by addition of a glycine enolate to a N-(tetrazol- 5-yl) imine followed by cyclisation. This route provided both the cis and the trans substituted azetidinones. The cis compounds possessed improved antibiotic activity as compared to the trans counterparts.