Tetrahedron letters

General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes

P Casara, K Jund, P Bey

Index: Casara, Patrick; Jund, Karin; Bey, Philippe Tetrahedron Letters, 1984 , vol. 25, # 18 p. 1891 - 1894

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Citation Number: 46

Abstract

Abstract The entitled allene derivatives have been prepared from the parent α-ethynyl amines and α-amino acids. The corresponding derivative of GABA, putrescine and phenylalanine have been found to be irreversible and time dependent inhibitors of GABA-T, ODC and bacterial AADC, respectively.