Synthesis of 4, 4-dialkoxy-3-piperidinols. Application to the synthesis of γ-acetate dehydropipecolinonitrile
MY Chang, TW Lee, CH Lin
Index: Chang, Meng-Yang; Lee, Tein-Wei; Lin, Chung-Han Tetrahedron, 2011 , vol. 67, # 26 p. 4892 - 4896
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Citation Number: 4
Abstract
Abstract The synthesis of 4, 4-dialkoxy-3-piperidinols 7 was carried out by the α-bromination of piperidin-4-one 5 with N-bromosuccinimide in acetic acid and alkoxide ion-mediated α, α- dialkoxyhydroxylation. Under acidic condition, trimethyl orthoformate-mediated reaction of compound 7a yielded aminodienylester 8 in the presence of Ph 3 P double bond; length as m-dash
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