De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl??1

…, M Zhou, L Han, Z Zhang, Q Ba, J Li, H Wang…

Index: Ding, Xiao; Li, Yan; Lv, Li; Zhou, Mi; Han, Li; Zhang, Zhengxi; Ba, Qian; Li, Jingquan; Wang, Hui; Liu, Hong; Wang, Renxiao ChemMedChem, 2013 , vol. 8, # 12 p. 1986 - 2014

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Citation Number: 9

Abstract

Abstract Considerable efforts have been made to the development of small-molecule inhibitors of antiapoptotic B-cell lymphoma 2 (Bcl-2) family proteins (such as Bcl-2, Bcl-x L, and Mcl-1) as a new class of anticancer therapies. Unlike general inhibitors of the entire family, selective inhibitors of each member protein can hopefully reduce the adverse side effects in chemotherapy treatments of cancers overexpressing different Bcl-2 family ...

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De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl??1

Abstract

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