Synthesis of alkyl chain-modified ether lipids and evaluation of their in vitro cytotoxicity

…, N Suesa, L Borras, C Lobato, P Banfi…

Index: Fos; Suesa; Borras; Lobato; Banfi; Gambetta; Zunino; Mauleon; Carganico Journal of Medicinal Chemistry, 1995 , vol. 38, # 7 p. 1216 - 1228

Full Text: HTML

Citation Number: 4

Abstract

N HC1 in THF, the primary hydroxyl group of the resulting diol was selectively protected with trityl chloride in pyridine and the secondary hydroxyl group was alkylated with methyl iodide and potassium hydride in benzene, to give cyanide 22. Grignard reaction with undecylmagnesium bromide or phenylmagnesium bromide in benzene and subsequent removal of the trityl protective group with 1 N HC1 in dioxane afforded alcohol 23, which ...