Multicatalytic Synthesis of α-Pyrrolidinyl Ketones via a Tandem Palladium (II)/Indium (III)-Catalyzed Aminochlorocarbonylation/Friedel− Crafts Acylation Reaction
TA Cernak, TH Lambert
Index: Cernak, Tim A.; Lambert, Tristan H. Journal of the American Chemical Society, 2009 , vol. 131, p. 3124 - 3125
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Citation Number: 76
Abstract
An oxidative carbonylation reaction that generates acid chloride functionality has been developed. Furthermore, this aminochlorocarbonylation reaction has been merged with a catalytic Friedel− Crafts acylation to produce a highly efficient tandem multicatalytic synthesis of pyrrolidinyl ketones. Significant variation of the aromatic nucleophile and substrate are shown. Two examples of incorporation of this method in triple-catalytic ...
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