3-[1-(2-Benzoxazolyl) hydrazino] propanenitrile derivatives: inhibitors of immune complex induced inflammation

…, JD Ratajczyk, RW DeNet, FA Kerdesky…

Index: Haviv; Ratajczyk; DeNet; Kerdesky; Walters; Schmidt; Holms; Young; Carter Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1719 - 1728

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Citation Number: 168

Abstract

3-[1-(2-Benzoxazolyl) hydrazino] propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied ...