Synthetic Communications

Toward the Total Synthesis of Bryostatin 11: Stereoselective Construction of the C13-Exocyclic Enoate in the C1–C16 Fragment

K Nakagawa-Goto, MT Crimmins

Index: Nakagawa-Goto, Kyoko; Crimmins, Michael T. Synthetic Communications, 2011 , vol. 41, # 20 p. 3032 - 3038

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Abstract

Abstract We have utilized a spiroketal template in an approach to the C1–C16 fragment of bryostatin. The stereoselective construction of an exocyclic enoate at C13 and insertion of a vinyl group on C15 were accomplished by using Peterson–Yamamoto olefination and copper-catalyzed addition of vinyl magnesium bromide, respectively.