Asymmetric syntheses of panclicins A–E via [2+ 2] cycloaddition of alkyl (trimethylsilyl) ketenes to a β-silyloxyaldehyde

…, B Pelotier, JM Pons, H Prideaux

Index: Kocienski, Philip J.; Pelotier, Beatrice; Pons, Jean-Marc; Prideaux, Heather Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 8 p. 1373 - 1382

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Citation Number: 23

Abstract

Panclicins A–E, pancreatic lipase inhibitors from Streptomyces, were synthesised in a modular fashion starting with three alkyl (trimethylsilyl) ketenes, two amino acids and a single aldehyde component,(3R)-3-(tert-butyldimethylsilyloxy) decanal 11. The lone ...