Journal of medicinal chemistry

Potential antitumor agents. 40. Orally active 4, 5-disubstituted derivatives of amsacrine

WA Denny, GJ Atwell, BC Baguley

Index: Atwell, Graham J.; Rewcastle, Gordon W.; Denny, William A.; Cain, Bruce F.; Baguley, Bruce C. Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 367 - 372

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Citation Number: 28

Abstract

The DNA-intercalating agent amsacrine is an effective drug for the treatment of human leukemias and lymphomas but has minimal solid tumor activity. As a first step in identifying analogues with a wider spectrum of activity, a comparison was made of the in vivo antileukemic (P-388) activity of amsacrine analogues given by oral (PO) and intraperitoneal (ip) routes. A series of 4-substituted and 4, 5-disubstituted derivatives all showed high ...