Synthesis of biaryls via a nickel (0)-catalyzed cross-coupling reaction of chloroarenes with arylboronic acids
S Saito, S Oh-tani, N Miyaura
Index: Saito, Syun; Oh-tani, Saori; Miyaura, Norio Journal of Organic Chemistry, 1997 , vol. 62, # 23 p. 8024 - 8030
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Citation Number: 254
Abstract
The cross-coupling reaction of arylboronic acid with chloroarenes to give biaryls was carried out in high yields at 70-80° C in the presence of a nickel (0) catalyst and K3PO4 (3 equiv) in dioxane or benzene. The nickel (0) catalyst in situ prepared from NiCl2⊙ L (L= dppf, 2PPh3)(3-10 mol%) and 4 equiv of BuLi at room temperature was recognized to be most effective. The reaction can be applicable to a wide range of chloroarenes having an ...
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