Design, Synthesis, and Structure–Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility

X Cao, Z Sun, Y Cao, R Wang, T Cai…

Index: Cao, Xufeng; Sun, Zhaoshuan; Cao, Yongbing; Wang, Ruilian; Cai, Tongkai; Chu, Wenjing; Hu, Wenhao; Yang, Yushe Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3687 - 3706

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Citation Number: 13

Abstract

Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity on the basis of the binding mode of albaconazole using molecular docking, along with SAR of antifungal triazoles. Tetrahydro-[1, 2, 4] triazolo [1, 5-a] pyrazine and tetrahydro-thiazolo [5, 4-c] pyridine nuclei were preferable to the other four fused-heterocycle nuclei investigated. Potent in vitro activity, broad spectrum and better water solubility were ...