Adenosine deaminase inhibitors. Synthesis of deaza analogs of erythro-9-(2-hydroxy-3-nonyl) adenine

…, G Cristalli, P Franchetti, M Grifantini…

Index: Antonini; Cristalli; Franchetti; Grifantini; Martelli; Lupidi; Riva Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 274 - 278

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Citation Number: 23

Abstract

" 2 16 3 k derivatives that led to discovery of EHNA, Schaeffer and Schwender have extensively studied and specified several factors that are important in complexation of the 9- substituent to the en~ yme.~ Until now, little attention has been paid to the heterocyclic moiety of EHNA, except for the work of Woo and Baker, which has provided some insight into ita geometric orientation and the contribution of the 6-amino group to binding.'l To ...