European journal of medicinal chemistry

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A 2 and leukotriene A 4 hydrolase

H Meng, Y Liu, Y Zhai, L Lai

Index: Meng, Hu; Liu, Ying; Zhai, Yujing; Lai, Luhua European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 160 - 167

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Citation Number: 5

Abstract

Dual function inhibitors targeting phospholipase A2 (PLA2) and leukotriene A4 hydrolase (LTA4H) may balance the arachidonic acid (AA) metabolic network and be used as new anti- inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A2 (hnps-PLA2) and human leukotriene A4 hydrolase (LTA4H-h) ...