Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis

JY Hwang, D Smithson, M Connelly, J Maier…

Index: Hwang, Jong Yeon; Smithson, David; Connelly, Michele; Maier, Julie; Zhu, Fangyi; Guy, Kiplin R. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 149 - 152

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Citation Number: 7

Abstract

A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.