A facile and practical synthesis of 1-aryl-3, 3, 3-trifluoropropynes.
T Hiyama, K Sato, M Fujita
Index: Hiyama, Tamejiro; Sato, Ken-Ichi; Fujita, Makoto Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 4 p. 1352 - 1354
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Citation Number: 39
Abstract
A facile and practical method for the synthesis of ArC≡ CCF 3 is described which involves (1) conversion of aldehydes ArCHO into ArCH= CClCF 3 with 1, 1, 1-trichloro-2, 2, 2- trifluoroethane, zinc powder, and acetic anhydride in one-pot and (2) dehydrochlorination with sodium t-butoxide or sodium amide/t-butyl alcohol.
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