Tetrahedron Letters

New condensing reagents for stereospecific synthesis of dinucleoside monophosphate aryl esters

E Ohtsuka, Z Tozuka, M Ikehara

Index: Ohtsuka, E.; Tozuka, Z.; Ikehara, M. Tetrahedron Letters, 1981 , vol. 22, # 45 p. 4483 - 4486

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Citation Number: 18

Abstract

Abstract Condensation of 5′-O-dimethoxytritylnucleoside 3′-O-(o-chlorophenyl) phosphates and 3′-O-benzoylnucleosides with a new condensing reagent, 2, 4, 6- triisopropylbenzenesulfonyl 5-(pyridin-2-yl) tetrazolide gave o-chlorophenyl ester of protected dinucleoside monophosphates which had a stereospecific configuration. The corresponding mesitylenesulfonyl derivative gave similar results.